That gave me 1g of Agmatine + 5g of citruline malate. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. Here's the downside, HAIR-LOSS. Thanks. Also, Rhodiola Rosea works great by itself. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. I take 2-3 doses of 700mg Agmatine per day. Experiment and make detailed protocols on how you feel when you increase your dosage. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. Is this dangerous to use with antidepressants and anti anxiety meds? I buy my noot powders from NootropicsDepot. Yes, always take a B-complex. There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. Preliminary googling looks like it helps boost serotonin. hide. Diastolic can vary in some people quite a bit but generally not as much as systolic. Looks like you're using new Reddit on an old browser. Research has found agmatine to be non-toxic when taken appropriately. Discussion and anecdotes are welcome! As someone else stated, agmatine is awesome. Press question mark to learn the rest of the keyboard shortcuts. Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. save. I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. Id' rather be depressed off Wellbutrin than lose anymore hair, because the biggest side effect is hair-loss. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatm … There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. I hope this helps, and I'll answer any questions. Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors. [212]", http://www.ncbi.nlm.nih.gov/pubmed/23583442. Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. I have a big bag of agmatine in my drawer! Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). Agmatine high is a common term among noot nuts, but that’s not at all accurate. Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body It works directly, and the effects persists after use. It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. ie, does it enhance or intensity the effects? Bupropion is an NDRI and has no obvious effect on serotonin reuptake or release, aside from possible secondary effects of the DRI function (which is weaker than the NRI). For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. Should I increase my dosage? 750mg is my dose. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). You can read my personal testimony to it there, it is very powerful. Systolic blood pressure amounts can vary greatly for a variety of factors. Can you explain further. Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. Agmatine is one of the most fascinating, and beneficial, substances. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. I take it once a week to save on cost rather than taking it daily. It is made from the amino acid known as arginine. I took 1g with 45mg of Nardil for a few weeks, no issues. [18][19] Potential Benefits of Agmatine. It calms NMDA activity enough without making you spacey and it seems to click with wb. and do not have the psychedelic side effects such as ketamine. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). admin 2 hours ago. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Doctors add an SSRI to wellbutrin very often but never an SNRI, because of additive effects on norepi. I have loss 1/3 of my hair, and enough was enough. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. Low quality posts will be removed. In dark corners of the deep web you hear of people using Agmatine to potentiate other compounds, and research suggests Agmatine is best used along side other drugs for maximum effect. I'd take ketamine over agmatine any day. That said, little research has been done on what the appropriate dosage should be. What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? It's not a side effect, it's what makes ketamine awesome. New comments cannot be posted and votes cannot be cast. report. I haven't notice any effect yet. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. I don’t think you understand the definition of side effect. I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. Rhodiola off Amazon, the NOW brand. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. 3 comments. I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. Does Agmatine work synergistically with Wellbutrin XL? I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. This is due to its positive impact on the nervous system. Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility. Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. We really don't have enough information to say, but theoretically worst thing that could happen is too much potentiation of the medication. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. Should I take it in the morning? When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. [15][16][17] Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). I didn't rage- which felt totally out of character for me. Take 1600mg of Piracetam and 300mg Alpha-GPC. Sort by. Common agmatine-containing foods include wine and beer. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). I have used it successfully to treat depression with ocassionally suicidal thoughts. Very interesting if true. Thanks! I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic. Are Agmatine and "agmatine sulfate" the same? Supplementation is a Nootropic that hasn ’ t think you understand the definition of side effect inhibits serotonin functions not. Despite holding some impressive potential bupropin and a B-Complex adding more agmatine of for! How i reacted substance in our body ; it 's one of the medication, liver, adrenal gland macrophages... Information to say, but again, consult with the professional potentiate opioids and how long you... 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